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In order to fill a fixed-term position in part-time (25,89 hours/week = 65%) at the earliest possible date or by August 01/2026, we are looking for 1

Researcher/PhD (m/f/x) for Medicinal Biophysics

The Karges research group is engaged in a wide range of interdisciplinary projects at the interface of synthetic chemistry, biochemistry, biophysics, and translational medicine. Our research focuses on the design and synthesis of novel metal complexes, characterization of photophysical properties, and the exploration of their biological activity against target proteins as well as in cancerous cells, with particular emphasis on understanding their potential for medical applications. We offer a dynamic and collaborative environment that combines expertise in chemistry, biology, physics, and medicine, providing opportunities to gain experience with cutting-edge methods. Candidates joining our team will contribute to innovative research at the forefront of medicinal chemistry and translational biophysics. Information to the activities of the research group can be found at our website (https://www.kargesgroup.ruhr-uni-bochum.de/).

Scope: part-time
Duration: fixed-term, 36 Monate
Start: at the earliest possible date or by August 01/2026
Apply by: 2026-05-11

Your tasks:

• Design and synthesize novel metal-based conjugates tailored for selective binding to target proteins, using advanced synthetic methodologies and comprehensive analytical characterization.
• Perform detailed photophysical investigations, including absorption and emission studies as well as reactive oxygen species generation, to provide insight into the photocatalytic properties and establish structure–property relationships.
• Conduct biochemical evaluation of target proteins, including expression, purification, and assessment of binding affinity.
• Plan and execute biological experiments in cancer cell models, including cytotoxicity assays, cellular uptake and localization studies, and mechanistic investigations of photoinduced cell death pathways.
• Integrate chemical, biochemical, and photophysical data to elucidate the mode of action of conjugates, with a focus on selective protein targeting and photodynamic activity.
• Document, analyze, and present research findings through reports, publications, and scientific presentations.
• Collaborate within an interdisciplinary research environment at the interface of chemistry, biology, physics, and medicine.

Your profile:

• Master of Science degree in chemistry, biochemistry, biology or a related discipline
• Experience with synthetic and spectroscopic methods
• Experience with protein expression is an advantage
• Experience with cell culture techniques is an advantage
• Ability to work independently and take initiative
• Good command of the English language
• Flexibility and adaptability
• Strong teamwork and collaboration skills

https://jobs.ruhr-uni-bochum.de/jobposting/2e298e65f4aaf31e4fb27ad12aa7b5cebf62bd4a0?ref=AfA